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Use of Resveratrol to treat experimental multiple Sclerosis
Principal
Investigator:
Prakash Nagarkatti (left)
Web Site
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Our studies are aimed at addressing the mechanism underlying use of CAM therapy in the treatment of MS. We are testing the potential of grape derived chemical, resveratrol in the treatment of MS using murine EAE models. We will be testing the central hypothesis that resveratrol treatment is effective against EAE through multiple pathways that include induction of apoptosis in myelin-specific T cells, suppression of DC functions, decreased T cell infiltration in the CNS due to down-regulation of homing receptors such as CD44 and upregulation of T regs.
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