Epigenetic pathways in resveratrol-induced amelioration of neuroinflammation

Principal Investigator Prakash Nagarkatti

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In this project we will test the hypothesis that resveratrol(RES) activates aryl hydrocarbon receptor (AhR) and/or estrogen receptor (ER) leading to induction of epigenetic pathways including DNA methylation and histone methylation/acetylation as well as miRNA regulation, which promote the differentiation of a unique type of suppressor cells called Myeloid-Derived Suppressor Cells (MDSCs) that ameliorate neuroinflammation seen in experimental autoimmune encephalomyelitis (EAE), an animal model of Multiple Sclerosis (MS). We will test RES-mediated epigenetic regulation of genes G-CSF, CD11b, Gr-1, Arg1 and iNOS in hematopoietic progenitor cells and MDSC.

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