Indole-mediated epigenetic regulation of T cells in colitis

Principal Investigator Mitzi Nagarkatti

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In this project we will test the central hypothesis that treatment with indole-3-carbinol (I3C) or diindolylmethane (DIM), activates aryl hydrocarbon receptor (AhR), leading to reciprocal regulation of proinflammatory T cells versus anti-inflammatory T cells via epigenetic pathways including DNA methylation and histone methylation/acetylation as well as miR induction, leading to suppression of inflammation in the colon.  We will investigate how I3C/DIM activate AhR leading to suppression of proinflammatory Th1/Th17cells and induction of Tregs/Th2 cells via epigenetic regulatory mechanisms using 3 models of colitis, 2 chemical and 1 microbial infection model.  We will test epigenetic regulation of FoxP3, IL-17 and IFN-γ.

Recent Publications