Epigenetic regulation of Nrf2 signaling pathway in American Ginseng-mediated suppression of inflammation in the colon

Principal Investigators Lorne Hofseth and Taixing Cui

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Taixing Cui Web Site

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In this project we will test the central hypothesis that nuclear factor erythroid-2 related factor 2 (Nrf2), a central endogenous regulator of intestinal antioxidant and phase 2 defenses, is a critical mediator of American ginseng (AG)-induced suppression of intestinal inflammation and that AG regulates its activity through epigenetic pathways We will test the efficacy of AG in three mouse models of colitis and colon cancer (chemical- and/or bacterial infection-induced models). We will delineate mechanisms by which AG and AG-Fraction V regulate Nrf2 signaling specifically on the Keap1:Nrf2 interface as well as examine epigenetic alterations including miRs that control Nrf2 and Keap1 genes.

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